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Presented for research literature review only Venter G et al

Personalized protocols based on individual biology are becoming increasingly feasible

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Metabolic pathway enrichment analysis revealed that CAR T cell products of LTR have significantly increased pools of TCA metabolites, nucleotide biosynthesis intermediates, sphingolipid metabolism, and intermediates in central energy metabolism, as well as significantly decreased nucleotide catabolic and tRNA metabolism intermediates, which is critical for T cell activation 10 , compared to those of STR (Fig

In some cases, additional tests, such as immunohistochemistry or molecular testing, may be performed on the biopsy sample to further characterize the tumor and guide personalized treatment approaches

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